• P Rabindra Reddy

      Articles written in Journal of Chemical Sciences

    • Stability of the ternary complexes of inosine in solution

      P Rabindra Reddy M Harilatha Reddy P R Prasad Reddy

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      The interaction of Cu(II), Ni(II), Co(II), Zn(II), Mn(II), Mg(II) and Ca(II) with inosine and secondary ligands histidine and glycine in a 1:1:1 ratio was determined by potentiometric equilibrium measurements at 35°C and 0.10 M (KNO3) ionic strength. The stability constants of the ternary complexes of xanthosine with histidine and glycine are also included for effective comparison. The ternary complexes were found to be stabler than the corresponding binary complexes. This higher stability of the ternary complexes is measured in terms of Δ logK which is the difference between the overall 1:1:1 stability constant and the corresponding 1:1 constant. Histidine forms stabler ternary complexes with inosine than does glycine. This is attributed to the π-accepting capacity of the imidazole ring of histidine and also to the stacking interaction between the purine part of inosine and the imidazole moiety of histidine.

    • Metal complexes of thymidine — a study of binary and ternary systems with bivalent and trivalent metal ions in solution

      P Rabindra Reddy C N Keerthi T K Adharani

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      The interaction of bivalent [Cu(II), Ni(II), Zn(II), Co(II), Mg(II), Ca(II)] and trivalent [La(III), Pr(III), Nd(III), Sm(III), Gd(III), Dy(III)] metal ions with thymidine both in binary and ternary systems have been investigated by potentiometric pH measurements at 35°C and 0·10M (KNO2) ionic strength. The secondary ligands used in this investigation were glycine, histidine, histamine,o-phenanthroline and α, α’-bipyridyl. The various stability constants pertaining to the above interactions were computed and compared. The influence of pH on the concentrations of several species present in aqueous solution, has been assessed. The effects of (i) charge on the metal ions, and (ii) the presence of a methyl group on the pyrimidine ring, on the stabilities of complexes have been assessed. A comparison with the corresponding constants of uridine has been made. Thymidine forms more stable complexes than uridine.

    • Interaction of zinc and cobalt with dipeptides and their DNA binding studies

      P Rabindra Reddy M Radhika K Srinivas Rao

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      Interactions of zinc and cobalt with peptides cysteinylglycine and histidylglycine have been studied. The binding modes were identified and geometry assigned. Stabilities of these complexes and their ability to bind DNA have been investigated. It is demonstrated that only zinc complexes bind DNA as compared to cobalt complexes

    • Synthesis and characterization of mixed ligand complexes of Zn(II) and Co(II) with amino acids: Relevance to zinc binding sites in zinc fingers

      P Rabindra Reddy M Radhika P Manjula

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      Mixed ligand complexes of Zn(II) and Co(II) with cysteine, histidine, cysteinemethylester, and histidinemethylester have been synthesized and characterized by elemental analysis, conductivity, magnetic susceptibility measurements, and infrared,1H NMR, TGA and FAB mass spectra. In these complexes, histidine, and histidinemethylester act as bidentate ligands involving amino and imidazole nitrogens in metal coordination. Similarly, cysteine, and cysteinemethylester also act as bidentate ligands coordinating through thiol sulphur and amino nitrogen. Tetrahedral geometry has been proposed for Zn(II) and Co(II) complexes based on experimental evidence.

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