• P Kolandaivel

      Articles written in Journal of Chemical Sciences

    • Study of atomic and condensed atomic indices for reactive sites of molecules

      P Kolandaivel G Praveena P Selvarengan

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      In this paper, we have introduced the atomic descriptors s(f)k to determine the local reactive sites of the molecular systems during electrophilic, nucleophilic and radical attacks. The condensed Fukui function and the newly introduced condensed atomic descriptor have been calculated for six different systems, namely glycine, alanine, aniline, BH2Cl,trans-FC(O)OF andm-anisidine. The individual atomic charges (gross charge) calculated by the MPA scheme have been used to calculate the condensed Fukui functions (fk) and the newly derived condensed atomic descriptors (sf)kα at B1-DZP level of theory. We carried out the calculation using the “stockholders” charge partitioning technique (i.e., Hirshfeld population scheme). The newly derived quantity gives the same reactive sites as the condensed Fukui functions, and the complexities associated with the negative Fukui functions are removed.

    • Reaction mechanism of 𝑂-acylhydroxamate with cysteine proteases

      R Shankar P Kolandaivel

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      The gas-phase reaction mechanism of 𝑂-acylhydroxamate with cysteine proteases has been investigated using ab initio and density functional theory. On the irreversible process, after breakdown of tetrahedral intermediate (INT1), small 1-2 anionotropic has been formed and rearranged to give stable by-products sulfenamide (P1) and thiocarbamate (P2) with considerable energy loss. While, on the reversible part of this reaction mechanism, intermediate (INT2) breaks down on oxidation, to form a stable product (P3). Topological and AIM analyses have been performed for hydrogen bonded complex in this reaction profile. Intrinsic reaction coordinates [IRC, minimum-energy path (MEP)] calculation connects the transition state between R-INT1, INT1-P1 and INT1-P2. The products P1, P2 and P3 are energetically more stable than the reactant and hence the reaction enthalpy is found to be exothermic.

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