Articles written in Journal of Chemical Sciences
Volume 132 All articles Published: 11 August 2020 Article ID 0105
Some of the chalcones and flavones are very efficient to facilitate the signal of death to the lung cancer cell through blocking the active site BH3 of Bcl-2 proteins. We designed a number of novel chalcones and flavones targeting the active site of the protein. Docking study showed that the designed compounds were very efficient as the reported compounds. We synthesized and characterized some of the designed compounds.2,3-Tetrasubstituted-2,3-dihydrobenzofuran-3-carboxamides were generated as novel products bybase-catalyzed condensation of o-hydroxyacetophenones and p-nitrobenzaldehyde in different alcohols. Detailed NMR spectroscopic analysis including COSY, homodecoupling and HETCOR (one bond as well aslong-range) studies established the structure of the compounds. Mechanistic paths have been suggested for the formation of the novel products.
Volume 132 All articles Published: 11 August 2020 Article ID 0103
Amyloids, a well-ordered b-sheet-enriched structural network, can be broadly defined as insoluble protein aggregates that are linked to a wide variety of diseases including systemic amyloidosis and some neurodegenerative disorders. Ferulic acid (FA), a phenolic acid, abundant in antioxidant and efficientpharmaceutical has beneficial effects against several ailments. Based on this, we have investigated the protective role of FA on amyloid formation of bovine b-lactoglobulin (b-lg), a model globular protein. Using a set of
Volume 132, 2020
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