• Mejda Daami-Remadi

      Articles written in Journal of Chemical Sciences

    • Access to new antimicrobial 4-methylumbelliferone derivatives

      Marwa Zayane Anis Romdhane Mejda Daami-Remadi Hichem Ben Jannet

      More Details Abstract Fulltext PDF

      Synthesis of some novel coumarin esters has been accomplished through iodine-catalyzed method using 4-methylumbelliferone as the starting material. Condensation of hydrazide, which was obtained in two steps from 4-methylumbelliferone, with some arylaldhydes provided hydrazone derivatives, while the reaction with phenylthioisocyanate leads to the thiosemicarbazide that evolved into two new compounds. Finally, condensation reaction of hydrazide with three diketones afforded new pyrrole and pyrazole derivatives. Structures of all synthesized compounds were established on the basis of spectroscopic methods including 1H NMR, 13C NMR and ES-HRMS. They were finally tested for their antimicrobial activity and the structure-activity relationship was discussed.

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