• Mariappan Periasamy

Articles written in Journal of Chemical Sciences

• Efficient resolution of (±)-rans-2,3-diphenylpiperazine using ($1S$)-(+)-10-camphorsulfonic acid and enrichment of enantiomeric purity of non-racemic 2,3-diphenylpiperazine using different achiral acids

Enantiomerically pure (𝑅,𝑅)-(+)-2,3-diphenylpiperazine with 98% $ee$ was obtained by resolution of the corresponding racemic mixture using ($1S$)-(+)-10-camphorsulfonic acid. The partially resolved enriched sample of (𝑆,𝑆)-(-)-2,3-diphenylpiperazine with 73% ee was purified to obtain samples of 97% ee using different achiral acids via the preparation of either homochiral or heterochiral hydrogen bonded aggregates.

• Chiral trans-1,2-diaminocyclohexane derivatives as chiral solvating agents for carboxylic acids

Efficient use of the readily accessible chiral $C_2$-symmetric acyclic diamines (1-2) as well as macrocyclic amines (3-5) containing trans-1,2-diaminocyclohexyl moiety as chiral solvating agents (CSA) for the determination of enantiomeric excess of representative carboxylic acids (6-7) and an amino acid derivative (8) is illustrated. The enantiomeric composition of different carboxylic acids estimated here by the 1H NMR method, based on the integration of the corresponding methine proton signals are in good correlation with that determined using HPLC method. The data are in accordance with the formation of multimolecular diastereomeric complexes in solution, which render good splitting of NMR signals for the enantiomers of representative carboxylic acids as well as for 𝑁-Ts-phenylglycine (up to $\Delta \Delta \delta = 0.295$ ppm, 118 Hz).

• # Journal of Chemical Sciences

Volume 134, 2022
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Continuous Article Publishing mode

• # Editorial Note on Continuous Article Publication

Posted on July 25, 2019