• Manish P Patel

      Articles written in Journal of Chemical Sciences

    • Synthesis of a novel class of some biquinoline pyridine hybrids via one-pot, three-component reaction and their antimicrobial activity

      Nimesh M Shah Manish P Patel Ranjan G Patel

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      A small library of novel class of biquinoline containing pyridine moiety were synthesized by a one-pot cyclocondensation of 2-chloro-3-formyl quinoline, active methylene compounds and 3-(pyridine-3- ylamino)cyclohex-2-enone in the presence of catalytic amount of sodium hydroxide. The protocol offers rapid synthesis of structurally diverse novel class of some biquinoline pyridine hybrids for antimicrobial screening. These compounds were screened for their antibacterial activity against Gram-positive bacteria (Bacillus subtilis, Clostridium tetani, Streptococcus pneumoniae), Gram-negative bacteria (Escherichia coli, Salmonella typhi, Vibrio cholerae) and antifungal activity against Aspergillus fumigatus, Candida albicans. Some of the biquinoline compounds were found to be more potent or equipotent than the first line standard drugs. The compounds were evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv strain using Lowenstein-Jensen medium. Compound 4g showed a compelling activity at 6.25 𝜇g/mL with a 96% inhibition and could be ideally suited for further modifications to obtain more efficacious compounds in the fight against tuberculosis.

    • Synthesis of 2-amino-4𝐻-chromene derivatives under microwave irradiation and their antimicrobial activity

      Nirav K Shah Nimesh M Shah Manish P Patel Ranjan G Patel

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      Libraries of 2-amino-4𝐻-chromenes, were efficiently synthesized via one-pot, three-component reactions of 5-chloro-3-methyl-1-aryl-4,5-dihydro-1𝐻-pyrazole-4-carbaldehyde (1a-c), 2-naphthols (2a-f) and malononitrile in the presence of catalytic amount of ammonium acetate under microwave irradiation. The protocol offers rapid synthesis of structurally diverse 2-amino-4𝐻-chromenes for biological screening. All the synthesized compounds were evaluated for their antimicrobial activity, and several compounds exhibited moderate to potent antimicrobial activity.

    • An efficient synthesis of 3'-indolyl substituted pyrido[1,2-𝑎]benzimidazoles as potential antimicrobial and antioxidant agents

      Harshad G Kathrotiya Manish P Patel

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      A new class of indole-based pyrido[1,2-𝑎]benzimidazole derivatives 4a-r have been synthesized by one-pot cyclocondensation reaction of 2-phenyl-1𝐻-indole-3-carboxaldehyde 1a-i, malononitrile 2 and 2-cyanomethylbenzimidazole 3a-b in the presence of catalytic amount of NaOH. In vitro antimicrobial activity of the synthesized compounds were investigated against a representative panel of pathogenic strains specifically three Gram-positive bacteria (Streptococcus pneumoniae, Clostridium tetani, Bacillus subtilis), three Gram-negative bacteria (Salmonella typhi, Vibrio cholerae, Escherichia coli) and two fungi (Aspergillus fumigatus, Candida albicans) using broth microdilution MIC (minimum inhibitory concentration) method. In vitro antioxidant activity was evaluated by ferric-reducing antioxidant power (FRAP) assay method. Compounds 4c, 4e, 4l and 4q have been found to be most efficient antimicrobial members while compounds 4h and 4p possess better ferric reducing antioxidant power.

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