Madhusudana Reddy Muthukur Bhoje Gowd
Articles written in Journal of Chemical Sciences
Volume 123 Issue 1 January 2011 pp 75-79
A simple, efficient and a versatile method for the synthesis of 5-substituted-1𝐻-tetrazoles by a [3+2]-cycloaddition reaction of arylnitriles with sodium azide in DMF using ZrOCl2·8 H2O as catalyst has been developed. The reactions work well at 100°C and give the desired products in excellent yield. The examples studied include arylnitriles having electron donating as well as electron releasing groups on the arene nucleus.
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