• MONIKA BANSAL

      Articles written in Journal of Chemical Sciences

    • Synthesis of 4-aryl-4,5-dihydro-1𝐻-indeno[1,2-𝑑]pyrimidines by Biginelli condensation and their antibacterial activities

      Ramandeep Kaur Monika Bansal Balbir Kaur Tulika Mishra Aruna Bhatia

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      A simple and efficient method has been developed for the synthesis of series of 4-aryl-1,3,4,5-tetrahydro-2𝐻-indeno[1,2-𝑑]pyrimidine-2-thiones through Biginelli’s one-pot multicomponent condensation reaction via microwave irradiations. Then, these thiones were converted to their S-alkylated/aralkylated derivatives. The prepared heterocyclic products were structurally confirmed by analytical and spectral data and evaluated for their antibacterial activities. The results showed that this skeletal framework exhibited marked potency as antibacterial agents. The compound 2-(Ethylthio)-4-(4-Hydroxy-3-methoxyphenyl)-4,5-dihydro-1𝐻-indeno[1,2-𝑑]pyrimidines 4b have shown antibacterial activity towards all the seven clinical isolates used.

    • A facile and efficient synthesis of Bis-thiazole from mono-thiazole

      MONIKA BANSAL

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      This paper describes a facile route for the synthesis of bis-thiazoles from mono-thiazole with aneco-friendly method. The synthetic procedure for the synthesis of bis-thiazoles from the reaction of 2-amino-4-tolyl thiazole with different aromatic aldehydes under microwave irradiations is discussed. Structures of thefinal products are characterized by IR, 1H and 13C- NMR spectra, DEPT-135 and mass spectrometry.

      A facile method is developed to synthesis bis-amino thiazole from easily synthesised mono thiazole. A series of bis thiazole were obtained with free amino groups which can be used for late-stage synthesis of new bis heterocyclic compounds.

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