• LUCIE RAROVA

      Articles written in Journal of Chemical Sciences

    • New oxygen-containing androstane derivatives: Synthesis and biological potential

      MARINA P SAVIC IVANA Z KUZMINAC DUSAN Ð S KORIC DIMITAR S JAKIMOV LUCIE RAROVA MARIJA N SAKAC EVGENIJA A DJURENDIC

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      New steroidal D-homo androstane derivatives with 5b,6b-epoxy-3,16-dicarbonyl, 6a- and 6bhydroxy-3,16-dicarbonyl and 3b,5a-dihydroxy-6,16-dicarbonyl moieties were synthesized and confirmed by NMR spectroscopy. Novel and starting compounds were evaluated for their potential cytotoxicity in vitro against seven human cancer cell lines (MCF-7, MDA-MB-231, PC3, HeLa, HT-29, A549 and CEM) and one human noncancerous cell line (MRC-5). The most sensitive cell line was MDA-MB-231 derived from female reproductive tissue, wherein all compounds showed moderate to strong cytotoxic activity. Also, new compound with 5b,6b-epoxy-3,16-dicarbonyl moieties showed strong cytotoxic activity against colon adenocarcinoma (HT-29). In this work, in silico ADME properties of novel compounds were assessed by comparing calculated molecular properties with Lipinski, Veber, Egan, Ghose and Muegge criteria

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