• K B Mathur

      Articles written in Journal of Chemical Sciences

    • Design and synthesis of systemically active enkephalin-like peptides

      K B Mathur

      More Details Abstract Fulltext PDF

      Following the discovery of enkephalins, it was observed that the mild analgesia evoked by them was completely dissipated within a few minutes even when they were injected directly into active brain sites. As these pentapeptides could serve as the prototypes of an entirely new class of analgesics, studies on their structure-function relationships were undertaken by a large number of investigators to get molecules which would produce profound and long-lasting analgesia even after systemic or oral administration. Various approaches that have helped in the successful achievement of this goal have been briefly reviewed.

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