• KRISHNA VANCHANAGIRI

      Articles written in Journal of Chemical Sciences

    • A new synthesis of tafamidis via zinc-MsOH mediated reductive cyclisation strategy

      KISHORE KARUMANCHI SENTHIL KUMAR NATARAJAN SUNIL GADDE KRISHNA VANCHANAGIRI KRISHNAMURTHY V R MOTURU

      More Details Abstract Fulltext PDF

      A practical zinc-MsOH mediated intra-molecular reductive cyclisation and its application in thesynthesis of tafamidis is presented starting from the readily available 3-hydroxy-4-nitrobenzoic acid as aprecursor. The key reductive cyclization step involves the use of a combination of the readily available zincand MsOH as the catalyst system. This methodology provides an attractive route to 2-aryl benzoxazoles from

      ortho-nitro phenols under mild reaction conditions. This methodology is developed on a multi-gram scale andwithout the need for column chromatography.

      A new and alternative zinc-MsOH mediated intra-molecular reductive cyclisation and its application in the synthesis of tafamidis is reported starting from the readily available 3-hydroxy-4-nitrobenzoic acid as precursor. This method provides an attractive route to 2-aryl benzoxazoles from ortho-nitro phenols under mild reaction conditions.

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