Articles written in Journal of Chemical Sciences
Volume 133 All articles Published: 7 April 2021 Article ID 0038
In this study, the viability of a wide range of crystalline aromatic and aliphatic carboxylic acids asorganocatalysts has been investigated for solvent-free Paal–Knorr pyrrole synthesis under microwave activation.Among these potential catalysts, crystalline salicylic acid proved to be a remarkable catalyst becauseits efficiency remained high even under low microwave power irradiation or a shorter reaction time for themodel reaction. The outstanding catalytic activity of salicylic acid allowed the Paal–Knorr cyclocondensationwith a turnover frequency up to 1472 h-1 which is unique in the context of a metal-free homogeneouscatalysis. The attractive feature of this organocatalyst is its assistance in ultrafast pyrrole synthesis with norisk of metal contamination.
Synopsis: A green and expeditious protocol for the synthesis of 2,5-dimethylpyrroles via combination of salicylic acid as catalyst (in its solid state) and microwaves has been introduced.
Volume 135, 2023
Continuous Article Publishing mode
Click here for Editorial Note on CAP Mode