KAUSAR RAZA MD
Articles written in Journal of Chemical Sciences
Volume 133 All articles Published: 21 April 2021 Article ID 0042
Four new ternary Oxovanadium(IV) complexes, [VO(L)(B1-4)](acac), where, L = (E)-2- (2-hydroxybenzylideneamino)-5-guanidinopentanoic acid (Argininesalisylidene) and B were 1H-imidazo-[4,5-f][1,10]-phenanthroline (B1) (1), 2-phenyl-1H-imidazo [4,5-f][1,10] phenanthroline (B2) (2), 2-(naphthalen-1-yl)-1H-imidazo [4,5-f][1,10] phenanthroline (B3) (3) or 1-(pyren-2-yl)-1H-imidazo[4,5-f][1,10] phenanthroline(B4) (4) were synthesized, characterized and photocytotoxicity in A549 cell were studied in dark andvisible light (400–700 nm, 10 J cm-2). Photochemistry of the complexes (1-4) related to the generation of singlet oxygen (1O2) was studied in detail. The presence of triplet excited state in the complexes was probedfrom perylene assay. Photo-activated generation of singlet oxygen from the complexes was probed by DPBF assay and the degree of photo-cytotoxicity of the complexes was related to their ability in photo-activated 1O2 generation. Complexes 4 exhibited remarkable photocytotoxicity in A549 cells with photo index (PI) ~ 16 invisible light (400–700 nm, 10 J cm-2) (IC50, 3.81 lμM), while complexes were almost less-toxic in dark (IC50,59.7 lμM). Intracellular ROS generation was studied from 2Ꞌ,7Ꞌ-dichlorofluorescein diacetate (DCFH-DA).Annexin V-FITC/PI assay suggested apoptotic nature of cell death. Overall, the remarkable photocytotoxicefficacy of the new Oxovanadium(IV) complexes (1-4) making them the potential photochemotherapeutic agents in lieu of porphyrin-based PDT agents.
Volume 134, 2022
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