• K R Acharya

      Articles written in Journal of Chemical Sciences

    • Crystal structure of 6-[(1-methyl-4-nitroimidazol-5-yl)thio] purine

      K R Acharya

      More Details Abstract Fulltext PDF

      6-[(l-methyl-4-nitroimidazol-5-yl)thio] purine, is an immunosuppressant derivative of the antitumour drug, 6-mercaptopurine. Crystals are monoclinic witha = 4.488(2),b = 31.886(4), c = 8.067(2)A and β= 105.99(2)° in the space group P21/c. The crystal structure was solved by direct methods using diffractometer data and refined by least squares to anR- index of 0.065 for 502 observed reflections. The molecule crystallizes in the N(9)-H tautomer form, in contrast to the N(7)-H tautomer form found in crystals of 6-mercaptopurine and assume a conformation in which the substituents on the sulphur atom are directed away from imidazole moiety of the purine

    • Conformational flexibility of longifolene

      K R Acharya S S Tavale T N Guru Row

      More Details Abstract Fulltext PDF

      The flexibility of the bicyclo[2.2.1]heptane-based tricyclic bridged system in longifolene is analysed based on x-ray structural data. In this context, the molecular structure of three differently substituted longifolenes has been analysed. The highly substituentdependent conformation provides scope for the synthesis of a variety of commercially oriented products.

  • Journal of Chemical Sciences | News

© 2021-2022 Indian Academy of Sciences, Bengaluru.