• Hongling Wang

      Articles written in Journal of Chemical Sciences

    • Microdetermination of human serum albumin by differential pulse voltammetry at a L-cysteine modified silver electrode

      Liyuan Lu Yanqin Zi Hongling Wang

      More Details Abstract Fulltext PDF

      A simple and highly sensitive electrochemical method for the determination of human serum albumin (HSA) using differential pulse voltammetry (DPV), based on a silver electrode modified with a self-assembled monolayer of L-cysteine, was developed. L-cysteine can be modified onto a silver electrode by covalent bonding through the sulfur to give stable and long-lived chemical electrodes. This electrode showed good sensitivity, selectivity, reproducibility and time stability in the determination of trace amounts of HSA by DPV technique. The detection limit can be as low as $4 \times 10^{-17}$ mol/L. The optimum conditions for the determination were carefully investigated. This method had been applied to the determination of HSA in human serum samples. The results were in agreement with those given in standard method.

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