HEMANT K GAUTAM
Articles written in Journal of Chemical Sciences
Volume 129 Issue 2 February 2017 pp 211-222 Regular Article
A series of quaternary ammonium derivatives of triazolyl pyranochromen-2-ones have been synthesized and characterized; their antibacterial potential were investigated against two gram negative (Pseudomonas aeruginosa and Escherichia coli) and two gram positive bacterial strains (Bacillus cereus and Staphylococcus aureus). In order to develop structure-activity relationship (SAR), the effect of varying the substituent (R) at the C-10 position of pyranochromen-2-one as well as the length of the spacer (n) between the triazolyl pyranochromen-2-ones and quaternary ammonium group, on the antibacterial activity of compoundshas been evaluated. Some of the screened compounds exhibited antibacterial potential against the studied strains in the microgram range.
Volume 134, 2022
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