The reaction of the [meso-tetra(p-chlorophenyl)porphyrinato]cadmium(II) complex ([Cd(TClPP)]) with an excess of 2-aminopyridine results in the formation of the corresponding axially ligated(2- aminopyridine)[meso-tetra(p-chlorophenyl)porphyrinato]cadmium(II)with the formula [Cd(TClPP)(2-NH₂Py)] (I). This five-coordinated metalloporphyrin was characterized by infrared, UV-visible, fluorescence,singlet oxygen, ¹H nuclear magnetic resonance and single crystal X-ray diffraction techniques. The in vitro antimicrobial activity of the free base porphyrin H₂TClPP porphyrin, the [Cd(TClPP)] starting material andcomplex (I) were screened against different species of bacteria. The assays showed an increase of antimicrobial potential due to the insertion of the cadmium metal into the H₂TClPP porphyrin and the axial coordination of 2-aminopyridine. Molecular docking approach indicated that [Cd(TClPP)(2-NH₂Py)] hashigher binding affinity with hydrogen-bonding interactions.

2-aminopyridine Cadmium(II) meso-chlorophenylporphyrin coordination compound abbreviated as [Cd(TClPP)(2-NH₂Py)] was synthesized and characterized. This compound shows interesting antibacterial properties. The molecular docking approach suggests that [Cd(TClPP)(2-NH₂Py)] has higher binding affinity with hydrogen bonding interactions.