Articles written in Journal of Chemical Sciences
Volume 132 All articles Published: 9 September 2020 Article ID 0122
Various aryl nitriles were readily synthesized from aerobic oxidation of substituted benzyl alcohols in deep eutectic solvent composed of choline chloride (ChCl) and p-toluenesulfonic acid (p-TsOH) in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), followed by condensation with hydroxylamine hydrochloride. High yields of corresponding nitriles have been obtained under mild reactions conditions. This strategy belongs to a novel and environmentally benign transition-metal-free one-pot cascade process for the synthesis of nitriles.
Volume 133, 2021
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