• GULZAR A BHAT

      Articles written in Journal of Chemical Sciences

    • Synthesis, characterisation, nuclease and cytotoxic activity of phosphate-free and phosphate-containing copper 4'-(N-methylpyridinium)-2,2':6' ,2'' terpyridine complexes

      GULZAR A BHAT RAIHANA MAQBOOL RAMASWAMY MURUGAVEL

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      Mononuclear Cu(II) pyridinium terpyridine based compounds, viz., [Cu(q- pytpy)(I)(CH3COO)](I)·(2H2O) (1) and [Cu(dipp)(dippH)(q-pytpy)]·(2H2O)(DMF) (2) were isolated by reacting Cu(OAc)2·H2O with 4'-(N-methylpyridinium)-2,2':6',2''-terpyridine (q-pytpy) in the presence of 2,6 diisopropylphenyl phosphate(dippH2). Both the new compounds were isolated as single crystals and characterised by spectroscopic (IR,ESI-MS, EPR, UV–Vis), thermogravimetric and microanalytical techniques. The molecular structures of both the compounds were determined in the solid-state by single crystal X-ray diffraction studies. Complexes 1 and 2 were evaluated for their nuclease and in vitro anti-tumor activities against human breast and colorectal cancer cell lines. The DNA cleavage and cytotoxic assays revealed that both 1 and 2 are effective in cleaving DNA, while the cytotoxic activity of 1 is better than 2 in both human colon and breast cancer cell lines.

    • Cyclic zinc organophosphate based expanded ditopic N,N-metalloligands

      GULZAR A BHAT RAMASWAMY MURUGAVEL

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      A new series of zinc phosphate based novel elongated ditopic N,N-metalloligands [Zn(Xdipp)(pyterpy)]2.2MeOH (X= H (1), Cl (2), Br (3), I (4)], exemplifying expanded 4,4-bipyridine spacer family, has been prepared by reacting 4-(4ꞋꞋ-pyridyl)-2,2:6,2ꞋꞋ-terpyridine (pyterpy), 2,6-iisopropylphenylphosphate (dippH2) or its para-halo functionalized derivatives X-dippH2 (X = Cl, Br, I) with Zn(OAc)2.2H2O in a mixture of solvents at room temperature. The formation of these metalloligands has been confirmed by their spectroscopic and analytical data. Solution and solid-state stability of these complexes have beenconfirmed by both mass spectroscopy and thermogravimetric analysis. The solid-state structures of 1–4 have further been established by single crystal X-ray diffraction studies, revealing that the N,N-distance in these systems can be expanded approximately to 23 A° , as against the 7 A° separation observed for 4,4-bipyridine.Compounds 2–4, which contain two pyridyl nitrogen centers and two C–X functionalities that are orthogonal to each other, could offer new possibilities in their use as metalloligand to build extended 2-D and 3-D solids

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