Articles written in Journal of Chemical Sciences
Volume 129 Issue 10 October 2017 pp 1603-1610 RAPID COMMUNICATION
Organocatalytic asymmetric Michael addition is considered among the most extensively studied, yet challenging stereoselective reactions due to the fact that the electrophilic prochiral carbon in Michael acceptor lies away from stereodirecting groups of the catalyst. Although there is a report on stereoselective organocatalysis in Michael addition employing monofunctional secondary amine, the use of monofunctional primary amine forthe said reaction is not reported till date. In fact, no monofunctional aminocatalyst is reported yet for the synthesis γ-nitro carbonyl compounds. Here we report our preliminary results on the enantioselective Michael addition of different ketones to nitro olefins catalysed by monofunctional primary amine (1) derived from d-fructose.
Volume 132 All articles Published: 13 February 2020 Article ID 0040
A series of coumarin-based trisubstituted methanes (TRSMs) having uracil scaffold was synthesised employing a green, chromatography-free, and a highly efficient sonochemical multicomponent reaction of diverse aldehydes with 1,3-dimethyl-6-aminouracil and 4-hydroxy-coumarin in the presence of acatalytic amount of DABCO at room temperature and tested their anthelmintic efficacy against helminth parasites,
Volume 133 All articles Published: 5 February 2021 Article ID 0016
Due to serious side effects of benzimidazoles such as apoptosis and mitotic arrest, development of
alternative anthelmintic drugs with comparable efficacy to target the acetylcholine receptors of parasites is
considered very important to control this parasitic disease. Here we have developed an excellent method for
synthesis of biscoumarins by employing a mild and efficient proline derived bifunctional thiourea catalyst
bearing pyrrolidine and thiourea catalytic sites and tested their anthelmintic activity against helminth parasites
Raillietina echinobothrida and Syphacia obvelata. The compounds 2a, 2j, 2k and 2o demonstrated much
stronger anthelmintic activity against Raillietina echinobothrida in comparison to the standard drug, Praziquantel.
Molecular docking simulations of the optimized compounds with b-tubulin showed excellent binding
interactions with several amino acid residues of the active site and the docking scores with b-tubulin were
found to be comparable to the
A series of biscoumarins were synthesized and they showed excellent anthelmintic properties in comparison to conventional benzimidazoles.
Volume 133, 2021
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