GIRIJ P SINGH
Articles written in Journal of Chemical Sciences
Volume 131 Issue 3 March 2019 Article ID 0022
Herein, we have described the synthesis of novel chiral cyclic phase transfer catalysts (PTCs). These catalysts are synthesized from proline, mandelic acid and tartaric acid by using simple synthetic methods with competitive yields. These chiral cyclic phase transfer catalysts have been characterized by 1H NMR and 13C NMR spectroscopy, IR spectroscopy and elemental analysis. The effectiveness of these novel chiral cyclic phase transfer catalysts was evaluated by applying them in the enantioselective epoxide synthesis from α, β unsaturated ketone (chalcone) and Darzens condensation. The obtained results show that the synthesized derivatives of proline, mandelic acid and tartaric acid are effectual as PTCs.
Volume 131 Issue 7 July 2019 Article ID 0064
The chiral metal complex produced in situ from (R)-6,6′-Diphenyl-BINOL and Ti(O−i−Pr)4 as a catalytic system for asymmetric sulfoxidation of aryl methyl and aryl benzyl sulfides in the presence of 70% aqueous TBHP as the oxidant has been investigated. The influence of variation of reagents mole ratios, temperature, solvent and oxidant was examined, and the optimized conditions were then used to oxidize a number of aryl methyl and aryl benzyl sulfides, producing sulfoxides in high enantiopurities (up to 90% ee) and good yields (up to 81%).
Volume 131 Issue 7 July 2019 Article ID 0067
Herein, we have explored the enantioselective Michael addition of various malonate esters to benzalacetophenone by successful utilization of chiral phase transfer catalysts derived from proline, mandelic acid and tartaric acid under mild phase transfer conditions. The obtained results signify that these chiral phasetransfer catalysts are efficacious towards enantioselective Michael addition as the use of it resulted in good enantioselectivity and appreciable chemical yields.
Volume 133 All articles Published: 7 April 2021 Article ID 0035
Herein, we have described a novel and concise synthesis of the potent angiotensin-convertingenzyme (ACE) inhibitor, benazepril hydrochloride (7) in trifluoroethanol
Synopsis: An efficient synthesis of benazepril hydrochloride using Ugi three-component reaction.
Volume 134 All articles Published: 20 April 2022 Article ID 0056
The given article describes the synthesis of 2-Oxazolidinone ring
Selective α-aminoxylation was achieved on corresponding aldehyde with great enantiomeric excess to get intermediate (5) using catalytic amount of low cost proline. The oxazolidinone ring was then constructed on common intermediate (5) which was then further converted to Oxazolidinone class compounds like Sutezolid and Eperezolid.
Volume 134, 2022
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