The bis- methyl imidazolium chloride-salophen Schiff base ligand as cationic Schiff base ligand (L₁) was synthesized by the reaction of methyl imidazoliumsalicylaldehyde chloride (S₁) and phenylendiamine.The phenylendiamine was also reacted by monosodium 5-sulfonatosalycilaldehyde (S₂) to give the bis-sodium sulfonate-salophen Schiff base ligand (L₂) as the anionic ligand. These two ligands were characterized by the ¹H-NMR, ¹³C-NMR, IR, UV–visible and mass spectroscopy, as well as elemental analysis.The ligand assisted PdCl₂ catalyst was investigated in the Suzuki-Miyaura reaction by using the L₁ and L₂ as cationic and anionic Schiff base ligands and different reaction conditions such as temperature, solvent and mol% of PdCl2 were optimized. The results revealed that the anionic ligand assistance had a better activity forthe catalytic system of PdCl₂ in Suzuki-Miyaura reaction