• DEVENDER SINGH

      Articles written in Journal of Chemical Sciences

    • Selective turn-on sensing of fluoroquinolone drugs by zinc complexes of amide-based ligands

      DIVYA PRABHA DEVENDER SINGH RAJEEV GUPTA

      More Details Abstract Fulltext PDF

      This work presents two mononuclear Zn(II) complexes of amide-based pincer ligands wheremigration of protons from the amidic N–H groups to the appended heterocyclic rings resulted in theirprotonation. The crystal structures of both the zinc complexes illustrated that such protonated heterocyclicrings created an H-bonding based secondary coordination sphere. Both complexes were utilized for theselective detection of fluoroquinolone antibiotics ciprofloxacin and norfloxacin. The two complexes exhibitedhigh selectivity for norfloxacin with nanomolar detection limits of 290 and 460. The binding studies werefurther supported with the NMR spectroscopic and the molecular docking studies that exhibited that anantibiotic interacts with a zinc complex that was responsible for its emission enhancement based detection.

      Synopsis This work presents two structurally characterized zinc complexes of amide-based ligands and their role in the selective detection of fluoroquinolone antibiotics ciprofloxacin and norfloxacin.

  • Journal of Chemical Sciences | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2021-2022 Indian Academy of Sciences, Bengaluru.