Chebrolu P Rao
Articles written in Journal of Chemical Sciences
Volume 112 Issue 3 June 2000 pp 399-399
Volume 112 Issue 3 June 2000 pp 428-428
Volume 120 Issue 2 March 2008 pp 237-247
Influence of alkali and alkaline earth ions on the 𝑂-alkylation of the lower rim phenolic-OH groups of 𝑝-
Role of alkali and alkaline earth ions on the formation of calixarene-amide derivatives through 𝑂-alkylation of the lower rim phenolic-OH groups in general and template action of K+ in particular have been explored. Na+ and K+ ions among alkali, and Ca2+ and Sr2+ ions among alkaline earth have shown tetra-amide derivatives bound to metal ion species. Among all these, potassium salts act as template and yields a K+ bound tetra-amide derivative where the charge is counter balanced by a calix arene-monoanion and the product is crystallographically characterized. Change in the amide precursor used in these 𝑂-alkylation reactions has no effect on the type of the amide derivative formed. Also demonstrated is a direct one-step reaction for the preparation of 1,3-di-amide derivative in high yield and low reaction period using CsHCO3.
Volume 124 Issue 6 November 2012 pp 1217-1228
Binding of metal complexes of C2-glucosyl conjugates with DNA has been established by absorption and fluorescence studies. Conformational changes occurred in DNA upon binding have been studied by circular dichroism. All these studies are suggestive that the metal complexes bind to DNA through intercalation. Binding of di-nuclear copper complex 5 was found to be stronger when compared to the other complexes studied. Copper complexes were found to cleave the plasmid DNA in the absence of oxidizing or reducing agent, whereas, zinc complexes do not cleave. Metal complexes have shown toxicity to the HeLa and MCF-7 cell lines.Morphological studies, western blot and FACS analysis are suggestive of apoptotic cell death induced by the metal complexes. Di-nuclear copper complexes were found to be better as compared to the mononuclear ones in binding, plasmid cleavage and also in causing more cell death.
Volume 126 Issue 4 July 2014 pp 1135-1141
2-Hydroxynaphthylidene derivatives of hydrazine, namely
Volume 132, 2020
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