• BANDANA SANASAM

      Articles written in Journal of Chemical Sciences

    • Photochemical and photocytotoxic evaluation of new Oxovanadium (IV) complexes in photodynamic application

      BANDANA SANASAM KAUSAR RAZA MD DULAL MUSIB MITHUN ROY

      More Details Abstract Fulltext PDF

      Four new ternary Oxovanadium(IV) complexes, [VO(L)(B1-4)](acac), where, L = (E)-2- (2-hydroxybenzylideneamino)-5-guanidinopentanoic acid (Argininesalisylidene) and B were 1H-imidazo-[4,5-f][1,10]-phenanthroline (B1) (1), 2-phenyl-1H-imidazo [4,5-f][1,10] phenanthroline (B2) (2), 2-(naphthalen-1-yl)-1H-imidazo [4,5-f][1,10] phenanthroline (B3) (3) or 1-(pyren-2-yl)-1H-imidazo[4,5-f][1,10] phenanthroline(B4) (4) were synthesized, characterized and photocytotoxicity in A549 cell were studied in dark andvisible light (400–700 nm, 10 J cm-2). Photochemistry of the complexes (1-4) related to the generation of singlet oxygen (1O2) was studied in detail. The presence of triplet excited state in the complexes was probedfrom perylene assay. Photo-activated generation of singlet oxygen from the complexes was probed by DPBF assay and the degree of photo-cytotoxicity of the complexes was related to their ability in photo-activated 1O2 generation. Complexes 4 exhibited remarkable photocytotoxicity in A549 cells with photo index (PI) ~ 16 invisible light (400–700 nm, 10 J cm-2) (IC50, 3.81 lμM), while complexes were almost less-toxic in dark (IC50,59.7 lμM). Intracellular ROS generation was studied from 2Ꞌ,7Ꞌ-dichlorofluorescein diacetate (DCFH-DA).Annexin V-FITC/PI assay suggested apoptotic nature of cell death. Overall, the remarkable photocytotoxicefficacy of the new Oxovanadium(IV) complexes (1-4) making them the potential photochemotherapeutic agents in lieu of porphyrin-based PDT agents.

  • Journal of Chemical Sciences | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2021-2022 Indian Academy of Sciences, Bengaluru.