Articles written in Journal of Chemical Sciences
Volume 133 All articles Published: 5 February 2021 Article ID 0016
Due to serious side effects of benzimidazoles such as apoptosis and mitotic arrest, development of
alternative anthelmintic drugs with comparable efficacy to target the acetylcholine receptors of parasites is
considered very important to control this parasitic disease. Here we have developed an excellent method for
synthesis of biscoumarins by employing a mild and efficient proline derived bifunctional thiourea catalyst
bearing pyrrolidine and thiourea catalytic sites and tested their anthelmintic activity against helminth parasites
Raillietina echinobothrida and Syphacia obvelata. The compounds 2a, 2j, 2k and 2o demonstrated much
stronger anthelmintic activity against Raillietina echinobothrida in comparison to the standard drug, Praziquantel.
Molecular docking simulations of the optimized compounds with b-tubulin showed excellent binding
interactions with several amino acid residues of the active site and the docking scores with b-tubulin were
found to be comparable to the
A series of biscoumarins were synthesized and they showed excellent anthelmintic properties in comparison to conventional benzimidazoles.
Volume 134, 2022
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