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- Anjali Gupta
  
  Articles written in Journal of Chemical Sciences
- Volume 124 Issue 2 March 2012 pp 437-449
  
  Ammonium derivatives of chromenones and quinolinones as lead antimicrobial agents
  
  Shilpi Gupta Seema Singh Abha Kathuria Manish Kumar Sweta Sharma Ram Kumar Virinder S Parmar Bharat Singh Anjali Gupta Erik Van Der Eycken Gainda L Sharma Sunil K Sharma
  
  More Details Abstract Fulltext PDF
  
  A series of novel ammonium derivatives were synthesized and examined for their antimicrobial efficacy. Comparison of antimicrobial spectrum revealed that compounds 9, 11, 16 and 23 had strong potential against pathogens in vitro. Cytotoxicity results showed compound 9 to be least toxic, it is non-toxic to A549 and U87 cells in MTT assay and exhibits marginal toxicity (15-20%) to human erythrocytes at a concentration of 1000 𝜇g/ml as compared to 100% lysis of cells by 31.25 𝜇g/ml of the standard drug amphotericin B. This compound has MIC values in the range of 1.95-31.25 𝜇g/disc in DDA against different pathogens and may considered to be an important lead antimicrobial molecule for further exploration.

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