A simple, mild and convenient method has been developed for the synthesis of 3,4,5-trialkyl-1,3-thiazole-2(3𝐻)-thione derivatives through one pot three-component reaction between a primary amine, carbon disulphide, and 𝛼-haloketone in the presence of potassium iodide at room temperature conditions. The products were obtained with excellent yield and appropriate reaction times. This reaction represents a rapid and unprecedented route to the described molecules that have biological specifications.

Reactions of benzoic acid derivatives and (𝐸)-cinnamic acid derivatives with 𝑁, 𝑁'-dialkyl carbodiimide proceed smoothly at room temperature and in neutral conditions to afford 𝑁-acylurea derivatives in high yields. The reaction proceeds smoothly and cleanly under mild conditions and no side reactions were observed.

Tetramethylguanidine-functionalized silica-coated iron oxide magnetic nanoparticles as aproductive and reusable catalyst have been applied for the one-pot three-component synthesis of furanone derivatives (4a–o). In addition to the characterization of all products by FT-IR,¹HNMR and ¹³CNMR spectroscopy, single-crystal X-ray analysis of ethyl 5-oxo-2-phenyl--(phenylamino)-2,5-dihydrofuran-3-carboxylate product has been made. Easy recrystallization and good-to-excellent yields (81–92%) of furanone derivatives are notable characteristics of this procedure. The catalyst identification was performed using FT-IR,XRD, SEM, TEM and TGA techniques. It is worth noting that the nanocatalyst can be recycled with an external magnet and reused for several times.