Amidinothioureas (7), (11) and (12) obtained by condensation of N,N-disubstituted thioureas with amide acetals have been used as starting materials for the synthesis of thiazoles. Thus, reaction with chloracetone and phenacyl bromides leads to ketones; the use of chloracetic ester in this reaction yields the thiazole-5-carboxylic ester (10).
Journal of Chemical Sciences
Volume 135, 2023 All articles Continuous Article Publishing mode
