• ASOK K MALLIK

      Articles written in Journal of Chemical Sciences

    • Novel chalcones as Bcl-2 inhibitor in lung cancer: docking, design and synthesis of 2,3-Tetrasubstituted-2,3-dihydrobenzofuran-3- carboxamides

      SANKAR P DEY NAYIM SEPAY ASOK K MALLIK AMARENDRA PATRA

      More Details Abstract Fulltext PDF

      Some of the chalcones and flavones are very efficient to facilitate the signal of death to the lung cancer cell through blocking the active site BH3 of Bcl-2 proteins. We designed a number of novel chalcones and flavones targeting the active site of the protein. Docking study showed that the designed compounds were very efficient as the reported compounds. We synthesized and characterized some of the designed compounds.2,3-Tetrasubstituted-2,3-dihydrobenzofuran-3-carboxamides were generated as novel products bybase-catalyzed condensation of o-hydroxyacetophenones and p-nitrobenzaldehyde in different alcohols. Detailed NMR spectroscopic analysis including COSY, homodecoupling and HETCOR (one bond as well aslong-range) studies established the structure of the compounds. Mechanistic paths have been suggested for the formation of the novel products.

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