• ASHISH RAINA

      Articles written in Journal of Chemical Sciences

    • Cyanide selective chemodosimeter in aqueous medium, on test strips and its application in real sample analysis

      ASHISH RAINA YADVENDRA SINGH KOMAL KUMAR YADAV TAMAL GHOSH

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      In this paper, synthesis, characterization and detection of CN- by the compound (N1E,N2E)-N1,N2-bis((2-hydroxynaphthalen-1-yl)methylene)oxalohydrazide (1) have been reported. Compound 1 is synthesized by the reaction of oxalyldihydrazide and 2-hydroxy-1-naphthaldehyde and characterized byFTIR, 1H NMR and ESI-Mass spectroscopy. UV–Visible spectral band of 1 is observed to be broadened and shifted to longer wavelength upon addition of CN- ion selectively in H2O-DMSO (8:2 v/v) medium. Based on the UV–Visible spectral data, the detection limit of cyanide ion for 1 is found to be 30.2 lM. Colourlesssolution of 1 changes to yellow in the presence of cyanide ion selectively. The same colour change is also observed on Whatman filter paper test strip. Fluorescence intensity of 1 is quenched due to the nucleophilic addition reaction of cyanide with one of the two imine carbons. 1H NMR titration of 1 with CN- ioncorroborates the reaction of the latter with one of the two imine carbons of the former, leading to the appearance of cyanomethyl proton signal at 6.15 ppm and consequently, its behaviour as chemodosimeter. The above mentioned chemodosimeter nature of 1 is also validated by ESI-Mass spectroscopy data. Compound 1 is capable for the detection of CN- in water for real samples with concomitant colour change

    • Selective colorimetric and fluorimetric detection of cyanide by malonohydrazide derivative and its live cell imaging

      ASHISH RAINA KOMAL KUMAR YADAV YADVENDRA SINGH TAMAL GHOSH

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      In the present study, the Schiff based compound (N′1E,N′3E)-N′1, N′3-bis((2-hydroxynaphthalen-1-yl)methylene)malonohydrazide (1) is synthesized via a facile method, characterized and furtherinvestigated for CN- sensing. Compound 1 is synthesized by the reaction of malonyldihydrazide and2-hydroxy-1-naphthaldehyde and its characterization is performed by FT-IR, 1H NMR and ESI-MS spectrometry.Absorption spectrum pattern of 1 is altered upon the addition of CN- ion selectively with thegeneration of a new band at 416 nm in H2O-DMSO (8:2 v/v) medium. The detection limit of 1 for CN- ion isassessed using UV-visible spectral data which is found to be 36.3 μM. The selective visual colour change isobserved upon the addition of CN- ion to colourless solution of 1 (colourless to yellow). A similar change incolour is also detected on Whatman filter paper test strips. Fluorescence intensity of sensor 1 is found to beenhanced on the addition of CN- ion. 1H NMR titration of 1 with CN- ion corroborates the binding of theformer using its naphthol OH and NH protons with the latter. Sensor 1 is also evaluated for intracellulardetection of CN- ion in A549 cells.

      Synopsis Compound 1 behaves as colorimetric and fluorimetic sensor for CN selectively in solution and on Whatman filter paper test strips. Binding of CN by 1 is supported by 1H NMR titration. Sensor 1 acts as an imaging reagent for live cell intra-cellular detection of CN in A549 cells.

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