Articles written in Journal of Chemical Sciences
Volume 130 Issue 9 September 2018 Article ID 0125
Silica-coated iron-oxide nanoparticles doped with Gd(III) complexes as potential double contrast agents for magnetic resonance imaging at different field strengths
ALEXEY STEPANOV SVETLANA FEDORENKO RUSTEM AMIROV IREK NIZAMEEV KIRILL KHOLIN ALEXANDRA VOLOSHINA ANASTASIYA SAPUNOVA RAFAEL MENDES MARK RÜMMELI THOMAS GEMMING ASIYA MUSTAFINA BORIS ODINTSOV
Abstract. In the present work, we have prepared the ~10 nm superparamagnetic iron-oxide nanoparticles by means of high-temperature decomposition of iron oleate precursor. Then they were coated with silica shell to impart water-solubility and an ability to accommodate paramagnetic Gd(III)-based complexes inside silica coating. All of the prepared nanoparticles form stable in time aqueous dispersions and show good negative or/and positive contrasting effect at different magnetic field strengths (0.47, 1.41, 14.1 T). It has been also exemplifiedthat the incorporation of [Gd(TCAS)] complexes into silica shell triggers a significant increase of the transverse relaxivity of the core–shell nanoparticles. The correlation between relaxometric properties and morphology ofthe obtained nanoparticles was revealed. The non-toxicity of the obtained nanoparticles along with their ability to shorten both transverse and longitudinal relaxation rates of water protons make them good candidates for their use as dual-mode contrast agents in MRI.
Volume 133 All articles Published: 22 April 2021 Article ID 0043
T2- and T1 relaxivities and magnetic hyperthermia of iron-oxide nanoparticles combined with paramagnetic Gd complexes
ALEXEY STEPANOV SVETLANA FEDORENKO RAFAEL MENDES MARK RU¨ MMELI LARS GIEBELER BRUNO WEISE THOMAS GEMMING SILVIO DUTZ DIANA ZAHN ILDUS ISMAEV RUSTEM AMIROV KIRILL KHOLIN ALEXANDRA VOLOSHINA ANASTASIYA SAPUNOVA SVETLANA SOLOVIEVA ASIYA MUSTAFINA
The present paper reports the synthesis of iron-oxide nanoparticles (diameter 12.8±2.2 nm) coated with silica shell doped with paramagnetic Gd(III)-based complexes. The resulting nanoparticles with a silica shell thickness of about 45 nm have an average diameter of 113.1±14.3 nm and feature high transverse and longitudinal relaxivities (356 and 25 mM-1 s-1, respectively) at 1.5 T and 25 °C on a medical whole body NMR scanner. It has been also revealed using magnetic heating measurements that the prepared core shell nanoparticles possess a high specific adsorption rate of around 236 W/g in aqueous media. The surface of the composite nanoparticles was decorated by amino-groups for a greater cellular uptake behaviour. The cell viability measurements reveal the concentration-dependent cytotoxicity of the nanoparticles, which agrees well with the high content of Gd(III) complexes in the nanomaterial. The obtained results show that the core-shell design of nanoparticles with superparamagnetic and paramagnetic parts can be promising for high transverse (and longitudinal) relaxivity as well as magnetic hyperthermia.
Volume 135, 2023
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