Hydrogenated soy phosphatidylcholine, tristearin and oleic acid were employed in preparing nanostructured lipid carriers (NLC). Surface modified NLCs (NLC_PEG) were formulated by adding polyethylene glycol 2000 (PEG 2000) in the dispersion medium along with Tween 60. Hot homogenization followed byultrasonication technique was used as the preparative procedure. 0.01% (w/v, g/mL) PEG 2000 was found to be the saturation limit for the studied formulations. Pyrazinamide (PYZ) was incorporated in NLC; the base and drug-loaded formulations were characterized by combined dynamic light scattering (DLS), differential scanning calorimetry (DSC), transmission electron microscopy (TEM) and atomic force microscopy (AFM). NLC_PEG was more stable than the conventional NLC formulations. Added PEG 2000 provided extra steric stability to NLC_PEG systems by introducing an additional layer over their surface. The presence of the additional layer of PEG 2000 also offered a preventative barrier towards the expulsion of surface accumulated PYZ. Considerableimprovement in entrapment efficiency (EE%), drug loading (DL%) and desirable sustained release profile could be achieved in NLC.