• AJIT DAS

      Articles written in Journal of Chemical Sciences

    • Gentisate-1,2-dioxygenase activity by an iron(II)-phenanthroline complex

      ABHRANIL DE DHANANJAY DEY AJIT DAS NIRANJAN KOLE BHASKAR BISWAS

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      In this work, we have synthesised and crystallographically characterized a mononuclear iron(II) complex, [Fe(phen)3](NO3)2 ·2H2O (1) (phen = 1,10-phenanthroline). Single crystal X-ray diffraction (SXRD) analysis revealed that 1 crystallizes in monoclinic system with P 1 space group. The lattice water molecules in 1 form a water-nitrate cluster, (H2O)2... (NO3)2 through strong H-bonding interaction mediated via iron(II) complex in a unique binding motif and provide additional stability to the compound in the solid state. This iron(II)complex is able to catalyze the cleavage of aromatic C-C linkage of 2,5-dihydroxybenzoic acid (Gentisic acid, GA) in oxygen environment. The iron(II) complex in the presence of two equivalent of triethylamine (Et3N) binds with GA stoichiometrically in acetonitrile medium at 25 C. Observation of GA-to-iron LMCT optical bands at 521 and 609 nm supports in situ generated iron-GA adduct in solution. This in situ generated iron-GA adduct reacts with molecular oxygen at the rate, kobs = 6.58×10−3 min−1 in acetonitrile and affords exclusively 2-oxo-4-hydroxy-hepta-3,5-dienedioic acid. The incorporation of both the oxygen atoms of molecular oxygen in the bio-mimicking activity of gentisate-1,2-dioxygenase by this iron(II)-phenanthroline complex remain arare example in scientific literature.

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