• AHMAD REZA MASSAH

      Articles written in Journal of Chemical Sciences

    • Synthesis, characterization and in vitro antibacterial activity of novel phthalazine sulfonamide derivatives

      MARZIEH ABBASI SEYED MOHAMAD REZA NAZIFI ZAHRA SADAT NAZIFI AHMAD REZA MASSAH

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      Several phthalazine derivatives were synthesized by the one-pot three-component condensation in good to high yields in the presence of diatomite-SO3H as a solid acid catalyst. Then, a series (n=14) of phthalazine sulfonamides were synthesized by the reaction phthalazine sulfonyl chloride and various amines under solvent-free conditions. The prepared compounds were screened for antibacterial activity against Escherichia coli (E. coli ATCC 25922) and Staphylococcus aureus (S. aureus ATCC 5213) as gram negative and positive respectively. Also, in silico physicochemical parameters of synthesized compounds were studied to predict absorption and permeability using Molinspiration online property calculation server.

    • Synthesis of 1,8‐dioxo-octahydroxanthenes utilizing nanodiatomite@melamine-SO3H as a novel heterogeneous catalyst under solvent-free conditions

      ELHAM DAVOODI ELHAM TAHANPESAR AHMAD REZA MASSAH

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      A new heterogeneous catalyst, nanodiatomite@melamine-SO3H, was introduced for synthesizing 1,8‐dioxo-octahydroxanthenes via multicomponent reactions of aldehydes and dimedone. The prepared catalyst was characterized by employing several techniques, including FT-IR, XRD, TGA, EDX, BET, SEM, and TEM. The products were obtained under solvent-free conditions, with high yields in short reaction times. The nanodiatomite@melamine-SO3H was reused five times without substantial activity loss.

      Nanodiatomite@melamine-SO3H as a novel heterogeneous catalyst was successfully developed and defined through several techniques. The catalyst showed excellent catalytic activity in the xanthene synthesis. The good points of this methodology are ease of product isolation, catalyst efficiency and recycling, cleaner reaction profile, and the procedure agreement with the green chemistry.

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