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Several phthalazine derivatives were synthesized by the one-pot three-component condensation in good to high yields in the presence of diatomite-SO3H as a solid acid catalyst. Then, a series (n=14) of phthalazine sulfonamides were synthesized by the reaction phthalazine sulfonyl chloride and various amines under solvent-free conditions. The prepared compounds were screened for antibacterial activity against Escherichia coli (E. coli ATCC 25922) and Staphylococcus aureus (S. aureus ATCC 5213) as gram negative and positive respectively. Also, in silico physicochemical parameters of synthesized compounds were studied to predict absorption and permeability using Molinspiration online property calculation server.
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A new heterogeneous catalyst, nanodiatomite@melamine-SO3H, was introduced for synthesizing 1,8‐dioxo-octahydroxanthenes
via multicomponent reactions of aldehydes and dimedone. The prepared catalyst was characterized by employing several techniques, including FT-IR, XRD, TGA, EDX, BET, SEM, and TEM. The products were obtained under solvent-free conditions, with high yields in short reaction times. The nanodiatomite@melamine-SO3H was reused five times without substantial activity loss.Nanodiatomite@melamine-SO3H as a novel heterogeneous catalyst was successfully developed and defined through several techniques. The catalyst showed excellent catalytic activity in the xanthene synthesis. The good points of this methodology are ease of product isolation, catalyst efficiency and recycling, cleaner reaction profile, and the procedure agreement with the green chemistry.
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Journal of Chemical Sciences
Volume 135, 2023
All articles
Continuous Article Publishing mode