One-pot synthesis of isoindole fused quinazolin 4-ones via intramolecular 1,3 hydride transfer in the presence of acid catalyst has been described. Substrate scope and mechanistic insights were investigated. Substituents on the amide side have a negligible influence on the key step and therefore the method have widescope for accessing various bicyclic core structure.
Journal of Chemical Sciences
Volume 132, 2020 All articles Continuous Article Publishing mode
