• YING LUO

      Articles written in Journal of Biosciences

    • MRTF-A regulates Ca2+ release through CACNA1S

      CHEN LIANG YAO XU ZHEN PENG YING LUO TONGCUN ZHANG

      More Details Abstract Fulltext PDF

      Gene therapy is considered a potential treatment for Duchenne muscular dystrophy (DMD). Researchers havebeen working on this for many years to find effective therapeutic targets. Here, we found that MRTF-A(myocardin-related transcription factor A) could activate the transcription of L-type Ca2+-channel-relatedprotein CACNA1S (calcium voltage-gated channel subunit alpha1 S) by binding to the CarG box in thepromoter of CACNA1S. However, increased phosphorylation and decreased expression of MRTF-A wereobserved, along with the expression of CACNA1S reduced in mdx mice. Further, the decreased expression andincreased phosphorylation of MRTF-A could inhibit the release of Ca2+ via CACNA1S. Therefore, MRTF-Amay be a potential molecular target for the diagnosis and treatment of DMD.

  • Journal of Biosciences | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2021-2022 Indian Academy of Sciences, Bengaluru.