Xingang Xu
Articles written in Journal of Biosciences
Volume 37 Issue 6 December 2012 pp 1005-1016 Articles
Zhaocai Li Yong Huang Feng Dong Wei Li Li Ding Gaoshui Yu Dan Xu Yuanyuan Yang Xingang Xu Dewen Tong
Swainsonine, a natural indolizidine alkaloid, has been reported to have antitumour effects, and can induce apoptosis in human gastric and lung cancer cells. In the present study, we evaluated the antitumour effects of swainsonine on several oesophageal squamous cell carcinoma cells and investigated relative molecular mechanisms. Swainsonine treatment inhibited the growth of Eca-109, TE-1 and TE-10 cells in a concentration-dependent manner as measured by MTT assay. Morphological observation, DNA laddering detection and flow cytometry analysis demonstrated that swainsonine treatment induced Eca-109 cell apoptosis
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