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    • Protein-rich extract of Musca domestica larvae alleviated metabolic disorder in STZ-induced type 2 diabetic rat model via hepatoprotective and pancreatic β-cell protective activities

      HANFANG MEI JIANHUA XU YINRU HE XIA YANG WENBIN LIU WEI TIAN YU ZENG JIAYONG ZHU

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      The study was designed to explore the beneficial effect of Musca domestica larvae extract (MDLE) on a metabolic disorderusing a diabetic rat model. Streptozotocin-induced diabetic rats were treated with or without MDLE. Blood glucose, insulinlevels, lipid profiles, and oxidative stress markers were measured. The morphological changes in the pancreas and liverwere determined, as well as insulin expression. The expression of glucose transporter 4 (GLUT4), phospho-adenosinemonophosphate-activated protein kinase (p-AMPK)/total AMPK, superoxide dismutase 1 (SOD1), catalase (CAT), andperoxisome proliferator-activated receptor gamma (PPAR𝛾) were detected. Compared with untreated diabetic rats, MDLEtreatedrats had decreased urine volume, food intake, and water intake, along with significantly lower levels of bloodglucose, malondialdehyde (MDA), plasma triglycerides, low-density lipoprotein (LDL), and total cholesterol. MDLE-treatedrats also had higher levels of SOD activity, high-density lipoprotein (HDL), and insulin. MDLE treatment partiallyrestored the β-cell population, improved the liver necrosis and islet cell damage, reversed the decreased expression ofGLUT4, phospho-AMPK, SOD1, and CAT in the liver, skeletal muscle and pancreatic tissue, and also increased theexpression of PPAR𝛾 in the liver and adipose tissue in diabetic rats. In conclusion, the obtained results suggest that MDLEcould possibly be used pharmacologically as an adjuvant for the treatment of diabetes.

    • Correction to: Protein-rich extract of Musca domestica larvae alleviated metabolic disorder in STZ-induced type 2 diabetic rat model via hepatoprotective and pancreatic b-cell protective activities

      HANFANG MEI JIANHUA XU YINRU HE XIA YANG WENBIN LIU WEI TIAN YU ZENG JIAYONG ZHU

      More Details Abstract Fulltext PDF

      In the December 2018 issue of the Journal of Biosciences, in the article titled ‘‘Protein-rich extract of Musca domestica larvaealleviated metabolic disorder in STZ-induced type 2 diabetic rat model via hepatoprotective and pancreatic b -cell protectiveactivities’’ by Hanfang Mei et al. (DOI: 10.1007/s12038-018-9804-z; Vol. 43, No. 5, pp. 969–983), the affiliations ofHanfang Mei have been incompletely mentioned as:1Guangdong Key Laboratory of Pharmaceutical Bioactive Substances, Guangzhou 510006, Guangdong, China2School of Basic Courses, Guangzhou 510006, Guangdong, China3Department of Biochemistry and Molecular Biology, Guangdong Pharmaceutical University, Guangzhou Higher EducationMega Center, Guangzhou 510006, Guangdong, ChinaThe correct affiliations should read as:1Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University,Guangzhou Higher Education Mega Center, Guangzhou 510006, Guangdong, China2School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou510006, Guangdong, China3Department of Biochemistry and Molecular Biology, Guangdong Pharmaceutical University, Guangzhou Higher EducationMega Center, Guangzhou 510006, Guangdong, China

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