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WEIQUAN XIE
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Volume 46 All articles Published: 17 February 2021 Article ID 0021 Article
WEIQUAN XIE LU LIU CHUANYONG HE MIN ZHAO RONG NI ZIXIONG ZHANG CHENGYU SHUI
It has been well investigated that circular RNAs (circRNAs) play important roles in various cancers. Thefunction of circ_0002711 and its underlying mechanisms in ovarian cancer (OC) remain unknown. qRT-PCRand western blot were performed to detect the expressions of circ_0002711, microRNA-1244 (miR-1244), andRho kinase 1 (ROCK1) in OC tissues and cells. MTT assay and colony formation assay were employed toevaluate cell proliferation. Detection of lactate production, glucose uptake, and ATP level and oxygen consumptionwere used to determine Warburg effect. Western blot was used to examine glycolysis or proliferationrelatedgenes. Dual-luciferase reporter assay and RIP pull down assay were used to address the relationshipamong circ_0002711, miR-1244, and ROCK1. In vivo tumor growth was evaluated in nude mice.Circ_0002711 was upregulated in OC tissues and cell lines. Circ_0002711 downregulation inhibited cellviability, colony formation ability and aerobic glycolysis. Circ_0002711 contained binding sites with miR-1244. Moreover, loss of miR-1244 undermined circ_0002711 downregulation-mediated function. ROCK1contained binding sites with miR-1244. MiR-1244 upregulation suppressed cell proliferation and aerobicglycolysis, which was rescued by enhanced expression of ROCK1. Circ_0002711 knockdown hamperedROCK1 expression by upregulating miR-1244 expression. Finally, decreased expression of circ_0002711inhibited tumor growth in vivo. Circ_0002711/miR-1244/ROCK1 axis regulated Warburg effect and tumorgrowth in vivo.
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Journal of Biosciences
Volume 48, 2023
All articles
Continuous Article Publishing mode
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Journal of Biosciences | News
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To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".
Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.
Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.
Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx
Posted on April 12, 2023< -
Editorial Note on Continuous Article Publication
Posted on July 25, 2019Click here for Editorial Note on CAP Mode
Forthcoming Special issue.
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