• VASILY M MERKULOV

      Articles written in Journal of Biosciences

    • Regulatory SNPs and their widespread effects on the transcriptome

      VASILY M MERKULOV ELENA YU LEBERFARB TATIANA I MERKULOVA

      More Details Abstract Fulltext PDF

      Currently, it is generally accepted that the cis-acting effects of noncoding variants on gene expression are a major factor forphenotypic variation in complex traits and disease susceptibility. Meanwhile, the protein products of many target genes forthe identified cis-regulatory variants (rSNPs) are regulatory molecules themselves (transcription factors, effectors, componentsof signal transduction pathways, etc.), which implies dramatic downstream effects of these variations on complexgene networks. Here, we brief the results of recent most comprehensive studies on the role of rSNPs in transcriptionalregulation across the genome.

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