Articles written in Journal of Biosciences
Volume 26 Issue 3 September 2001 pp 383-390 Review
Orally active insulin mimics: where do we stand now?
The war against diabetes through the development of new drugs is an ongoing continuous process to counter the alarming global increase in the prevalence of diabetes and its complications, particularly in developing countries like India. Unfortunately, the speed with which our knowledge of diabetes and its effects is expanding is not matched by the availability of new drugs. Following the identification of the insulin receptor (IR), its intrinsic kinase activity and molecular cloning, many studies have looked at IR as an ideal drug target. This review summarizes in brief the latest advancements in this field with particular reference to the current situation in respect of the development of orally active insulin mimetics in the treatment of type 2 diabetes.
Volume 28 Issue 6 December 2003 pp 715-721 Articles
Curcumin-induced inhibition of cellular reactive oxygen species generation: Novel therapeutic implications
M Balasubramanyam A Adaikala Koteswari R Sampath Kumar S Finny Monickaraj J Uma Maheswari V Mohan
There is evidence for increased levels of circulating reactive oxygen species (ROS) in diabetics, as indirectly inferred by the findings of increased lipid peroxidation and decreased antioxidant status. Direct measurements of intracellular generation of ROS using fluorescent dyes also demonstrate an association of oxidative stress with diabetes. Although phenolic compounds attenuate oxidative stress-related tissue damage, there are concerns over toxicity of synthetic phenolic antioxidants and this has considerably stimulated interest in investigating the role of natural phenolics in medicinal applications. Curcumin (the primary active principle in turmeric,
Volume 48, 2023
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