• TATIANA I MERKULOVA

      Articles written in Journal of Biosciences

    • Brain-derived neurotrophic factor and early-life stress: Multifaceted interplay

      NATALYA P BONDAR TATIANA I MERKULOVA

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      The brain-derived neurotrophic factor (BDNF) is a key regulator of neural development and plasticity. Longtermchanges in the BDNF pathway are associated with childhood adversity and adult depression symptoms.Initially, stress-induced decreases in the BDNF pathway were found in some studies, but subsequent reportsindicated the relationship between stress and BDNF to be much more complex, and the concept wassignificantly revised. In the present mini-review, we focus on the structure and regulation of the Bbnf geneas well as on the stress–BDNF interactions under early-life adverse conditions.

    • Regulatory SNPs and their widespread effects on the transcriptome

      VASILY M MERKULOV ELENA YU LEBERFARB TATIANA I MERKULOVA

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      Currently, it is generally accepted that the cis-acting effects of noncoding variants on gene expression are a major factor forphenotypic variation in complex traits and disease susceptibility. Meanwhile, the protein products of many target genes forthe identified cis-regulatory variants (rSNPs) are regulatory molecules themselves (transcription factors, effectors, componentsof signal transduction pathways, etc.), which implies dramatic downstream effects of these variations on complexgene networks. Here, we brief the results of recent most comprehensive studies on the role of rSNPs in transcriptionalregulation across the genome.

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