Articles written in Journal of Biosciences

    • Pattern of genomic variation in SARS-CoV-2 (COVID-19) suggests restricted nonrandom changes: Analysis using Shewhart control charts


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      SARS-CoV-2 is a member of the Coronavirus family which recently originated from the Wuhan province ofChina and spread very rapidly through the world infecting more than 4 million people. In the past, otherCoronaviruses have also been found to cause human infection, but not as widespread as COVID-19. SinceCoronavirus sequences constantly change due to mutation and recombination, it is important to understand thepattern of changes and likely path the virus can take in the future. In this study, we have used the Shewhartcontrol chart to identify and analyze hypervariable (hotspots) and hypovariable (coldspots) regions of the virus.Our analysis shows that SARS-CoV-2 has changed in a few regions of the genome. Analysis of SARS-CoV-1and MERS sequences suggests that over time, mutations start accumulating in different regions and most likelySARS-CoV-2 may also follow a similar path. The results suggest a possible emergence of modified virusesover some time.

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