Susan Kemper
Articles written in Journal of Biosciences
Volume 15 Issue 3 September 1990 pp 187-191
Functional and pathological significance of phospholipid asymmetry in erythrocyte membranes
Robert A Schlegel Susan Kemper Patrick Williamson
The normal asymmetric distribution of phospholipids in the plasma membrane is perturbed in erythrocytes from patients with chronic myelogenous leukemia. Since experimentally-produced lipid-symmetric erythrocytes are more interactive with cells of the reticuloendothelial system than are their lipid-asymmetric counterparts, the biological recognition of chronic myelogenous leukemia erythrocytes by the reticuloendothelial system was examined. With one exception, all erythrocyte samples from patients with chronic/benign chronic myelogenous leukemia were more adherent to endothelial cells and more readily phagocytosed by macrophages
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