• Sunanda Vejare

      Articles written in Journal of Biosciences

    • Importance of determining viability ofMycobacterium leprae inside macrophages—anin vitro method using uracil

      Sunanda Vejare P R Mahadevan

      More Details Abstract Fulltext PDF

      It has been demonstrated thatMycobacterium leprae, are caPable of taking uP uracil and incorPorating it into trichloroacetic acid-insoluble materials, both as free susPension of bacteria, as well as when they are inside the macrophages, a host cell for theirin vivo survival. Same amount of bacteria show better incorPoration inside macroPhages than as free bacterial susPension. Both tyPes of incorPoration are inhibited by rifamPicin an antileProsy drug and an RNA synthesis inhibitor. Thus uracil uPtake byMycobacterium lePrae inside macroPhages has been used for standardising a raPidin vitro viability assay for the leProsy causing bacteria.

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