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    • Sun-Joo Oh

      Articles written in Journal of Biosciences

    • Volume 39 Issue 4 September 2014 pp 673-682 Articles

      Skin anti-photoaging properties of ginsenoside Rh2 epimers in UV-B-irradiated human keratinocyte cells

      Sun-Joo Oh Sihyeong Lee Woo-Yong Choi Chang-Jin Lim

      More Details Abstract Fulltext PDF

      Ginseng, one of the most widely used herbal medicines, has a wide range of therapeutic and pharmacological applications. Ginsenosides are the major bioactive ingredients of ginseng, which are responsible for various pharmacological activities of ginseng. Ginsenoside Rh2, known as an antitumour ginsenoside, exists as two different stereoisomeric forms, 20(𝑆)-ginsenoside Rh2 [20(𝑆)-Rh2] and 20(𝑅)-ginsenoside Rh2 [20(𝑅)-Rh2]. This work aimed to assess and compare skin anti-photoaging activities of 20(𝑆)-Rh2 and 20(𝑅)-Rh2 in UV-B-irradiated HaCat cells. 20(𝑆)-Rh2, but not 20(𝑅)-Rh2, was able to suppress UV-B-induced ROS production in HaCat cells. Both stereoisomeric forms could not modulate cellular survival and NO level in UV-B-irradiated HaCat cells. Both 20(𝑆)-Rh2 and 20(𝑅)-Rh2 exhibited suppressive effects on UV-B-induced MMP-2 activity and expression in HaCat cells. In brief, the two stereoisomers of ginsenoside Rh2, 20(𝑆)-Rh2 and 20(𝑅)-Rh2, possess skin anti-photoaging effects but possibly in different fashions.

  • Journal of Biosciences | News

      Forthcoming Special issue.


    • To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".


      Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.


      Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.


      Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx

      Posted on April 12, 2023
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      Posted on July 25, 2019

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