Articles written in Journal of Biosciences
Volume 19 Issue 2 June 1994 pp 267-275
Phenotypic variability for abdominal pigmentation in females of an Indian natural population of
Volume 42 Issue 3 September 2017 pp 373-382 Brief communication
Clinical trials using human Mesenchymal Stem Cells (MSCs) have shown promising results in the treatment of variousdiseases. Different tissue sources, such as bone marrow, adipose tissue, dental pulp and umbilical cord, are being routinelyused in regenerative medicine. MSCs are known to reduce increased oxidative stress levels in pathophysiological conditions.Differences in the ability of MSCs from different donors and tissues to ameliorate oxidative damage have not beenreported yet. In this study, for the first time, we investigated the differences in the reactive oxygen species (ROS) reductionabilities of tissue-specific MSCs to mitigate cellular damage in oxidative stress. Hepatic Stellate cells (LX-2) and cardiomyocyteswere treated with Antimycin A (AMA) to induce oxidative stress and tissue specific MSCs were co-cultured tostudy the reduction in ROS levels. We found that both donor’s age and source of tissue affected the ability of MSCs toreduce increased ROS levels in damaged cells. In addition, the abilities of same MSCs differed in LX-2 and cardiomyocytesin terms of magnitude of reduction of ROS, suggesting that the type of recipient cells should be kept in consideration whenusing MSCs in regenerative medicine for treatment purposes.