Sandeep Kumar
Articles written in Journal of Biosciences
Volume 33 Issue 2 June 2008 pp 269-277 Articles
Baby P S Chakrapani Sandeep Kumar Jamuna R Subramaniam
Most drugs and xenobiotics induce the expression of cytochrome P450 (CYP) enzymes, which reduce the bioavailability of the inducer and/or co-administered drugs. Therefore, evaluation of new drug candidates for their effect on CYP expression is an essential step in drug development. The available methods for this purpose are expensive and not amenable to high-throughput screening. We developed a fluorescence-based
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