• SWETA SIKDER

      Articles written in Journal of Biosciences

    • Evolution of genome organization and epigenetic machineries

      TAPAS K KUNDU SWETA SIKDER

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      The unit content of DNA in a living organism containing all of its genes is referred to as ‘genome’, which forms the basis oflife and heredity. In the path of evolution from a single-cellular prokaryotic life to multi-cellular eukaryotic system, thegenome has become more and more complex not only in the context of size but also in sequence and content. Although thesize of the genome does not directly correlate with the complexity and hierarchy of a living organism, in the eukaryoticsystem with restricted nuclear size, disproportionately higher size of DNA is packed into a highly ordered manner (Kumariet al., in Kundu (eds) Epigenetics: development and disease. Subcellular biochemistry, Springer, Dordrecht, 2013). Thispackaging of genome with the assistance of protein and RNA is not a unique feature of the eukaryotic system alone. In fact,even in a tiny prokaryotic cell, to reduce the volume and to restrict the signal dependent availability of the genomic material(DNA), packing of genome is essential. In this brief article, we shall try to put forward a concept of genome organizationand epigenetic machineries to assist the functional ability of the genomic material in the evolutionary perspective.

    • Regulation of epigenetic state by non-histone chromatin proteins and transcription factors: Implications in disease

      SWETA SIKDER STEPHANIE KAYPEE TAPAS K KUNDU

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      Besides the fundamental components of the chromatin, DNA and octameric histone, the non-histone chromatinproteins and non-coding RNA play a critical role in the organization of functional chromatin domains. Thenon-histone chromatin proteins therefore regulate the transcriptional outcome in both physiological andpathophysiological state as well. They also help to maintain the epigenetic state of the genome indirectly.Several transcription factors and histone interacting factors also contribute in the maintenance of the epigeneticstates, especially acetylation by the induction of autoacetylation ability of p300/CBP. Alterations of KATactivity have been found to be causally related to disease manifestation, and thus could be potential therapeutictarget.

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